Using computation to explore the natural world
Location: King Henry Building
Our Sequencing and Bioinformatics laboratory is the hub for working with a variety of DNA and RNA sequencing tools, as well as high-throughput nanopore sequencers.
Through hands-on experiments, you'll see how DNA and RNA pass through tiny pores and are then decoded into their constituent parts by machine learning algorithms.
The facility includes a wide range of computational tools to analyse nanopore sequencing data and other next-generation sequencing platforms. Additionally, we maintain pipelines for sequencing applications such as whole (meta) genome assemblies, RNA sequences, targeted sequences, and amplicon sequences.
Our lab collaborates on a wide range of research projects, especially those that use and (ONT) for high-throughput sequencing, and has recently served as a virus Genomics UK (COG-UK) . We also host a range of research projects within the Centre for Enzyme Innovation (CEI), exploring the genomes of naturally occurring microorganisms to identifying enzymes with potential industrial applications.
Equipment and amenities
- MinION nanopore sequencer (Oxford Nanopore Technologies)
- GridION nanopore sequencer (Oxford Nanopore Technologies)
- P2Solo PromethION nanopore sequencer (Oxford Nanopore Technologies)
- VolTrax automatic sample preparation (Oxford Nanopore Technologies)
- Qubit 4 fluorometer (Invitrogen)
- DS-11 Spectrophotomer (Denovix)
- 4150 TapeStation (Agilent)
- Bioinformatics High Performance Computing (HPC) cluster, which includes:
- Four 24-CPU compute nodes with 768 GB RAM
- Two 24-CPU compute nodes with 384GB RAM
- One GPU compute node with two V100 Tesla GPUs and 1,024 GB RAM
- One head node with 48 CPUs and 384 GB RAM
- One PB of redundant data storage connected via a 10GbE Network
Contact us
If you're interested in our sequencing and bioinformatics facilities – please email seqandbio@port.ac.uk or call +44 (0) 23 9284 2043.
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Where to find us
Sequencing and Bioinformatics Group laboratory
King Henry Building
King Henry I Street
Portsmouth
PO1 2DY